As part of an invitation-only guest lecture at the renowned Harvard University in the USA in December 2024, Professor Tobias Esch, founder and director of the Institute for Integrative Healthcare and Health Promotion (IGVF) and scientific director of the University Outpatient Clinic for Integrative Healthcare and Naturopathy (UnIG), shed light on the neurobiological aspects of nutritional regulation and the physiological foundations of motivation, behavioral change and mindfulness. The BERN concept developed by Tobias Esch and already successfully implemented in the university outpatient clinic served as a practical example of the scientific implementation of the concepts presented by Tobias Esch. The ZPP-certified stress management and health promotion approach is based on the pillars of Behavior, Exercise, Relaxation and Nutrition and met with great interest during the well-attended lecture from the international experts represented on site and virtually.